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Mirtazapine is also a good choice in depressed patients with significant anxiety or insomnia. Cost to the patient will be higher, depending on prescription filling fee*—Estimated cost to the pharmacist based on average wholesale prices, for one month's therapy at the lowest usual dosage level, in Red book. Selective serotonin reuptake inhibitors (SSRIs) have become the drugs of choice in the treatment of depression.3 Generally, either the older tricyclic antidepressants or the newer antidepressants are used for second-line therapy.4 During the first few years of introduction to the U. market, it is reasonable for an antidepressant such as mirtazapine to be reserved for use in patients who do not tolerate or do not respond to initial therapy with SSRIs.

Although mirtazapine has been used successfully in Europe for a number of years, its place in the care of patients with depression in the United States has not yet been established.*—Estimated cost to the pharmacist based on average wholesale prices, for one month's therapy at the lowest usual dosage level, in Red book. Mirtazapine is a tetracyclic piperazinoazepine, which has a different structure from any other currently used antidepressant.

At higher doses, it acts more on the norepinephrine receptors and has less of a sedating effect. Do NOT take more than 15mg if you want to use it for sleep. I can take as little as 5mg (a tiny chunk off of a 30mg pill) to feel sedated.afterglow is this from personal experience?

because ive been taking mirtazapine for 2 years now and 30 mg knocks me out within 20 minutes, for over 9 hours.

sure different effects show their face at higher doses, but it doesnt mean that the most potent anti histamine on the market (remeron) doesnt stop being an anti histamine. its still going to make you sleep....regardless of NEYes, this is from personal experience. When I was feeling too drowsy from 15 mg mirtazapine, my psych up'd the dose to 30mg to mediate the sedating effect. I was on 15mg for 1 year and then 30mg for another year.afterglow is this from personal experience?

sure different effects show their face at higher doses, but it doesnt mean that the most potent anti histamine on the market (remeron) doesnt stop being an anti histamine. its still going to make you sleep....regardless of NE I totally agree.

(Please include the source of your information or explain why) Thanks!

hey koolstof I started remeron (it is known as Zispin in the uk) 6 days ago and im on 15mg, how comes your on such a high dosage 60mg seems quite high to me they dont know why but it seems to be true that the lower the dosage the better sedation it offers.

It demonstrates linear kinetics over its usual dosage range and reaches peak plasma level approximately two hours after an oral dose.11 The elimination half-life is 20 to 40 hours, so a steady state is reached in approximately five days.Or could it just be that I was getting used to this medications side-effects (I'm talking about a timespan of 10 days, with day 1 as the first day I took Remeron. Day 10 is now: I alternate dosage: one day 30mgs, another day 60 mgs and I can function normally, do not feel like a zombie anymore).IN SUMMARY: If you increase the dosage of Remeron/mirtazapine does this mean less sedation?I used to be on remeron aswell, and I could take 45mg and still feel the sedating effects.Sounds a bit to me like you are the one who knows nothing about mirtazapine and jumps to conclusions as soon as you hear the word 'norepinephrine'.Physicians who are concerned about the risks of elevated lipid levels and agranulocytosis may choose to reserve mirtazapine as a third-line choice.